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吕平博士-教授

发布时间:2019-07-23   浏览次数:0

吕平,女,教授、博士生导师。现在河北医科大学药理教研室工作。主要从事神经功能改变与听觉障碍关系的研究。


大学开始受教育经历:

1996.9-2001.7     河北医科大学 临床医学系  本科

2001.9-2004.7     河北医科大学  药理学     硕士   导师:王永利 教授

2004.9-2007.7     河北医科大学  药理学     博士   导师:王永利 教授

研究工作经历:

2007.7-2011.7     University of California, Davis      博士后

2011.7-2012.11     河北医科大学   药理教研室      讲师

2012.11-2016.12    河北医科大学   药理教研室     副教授、硕士生导师

2016.12-2017.11    河北医科大学   药理教研室     副教授、博士生导师

2017.11-至今       河北医科大学   药理教研室     教授、博士生导师


发表的主要论文


1 Shen H, Liu W, Geng Q, Li H, Lu M, Liang P, Zhang B, Yamoah EN, Lv P. Age-Dependent Up-Regulation of HCN Channels in Spiral Ganglion Neurons Coincide With Hearing Loss in Mice. Front Aging Neurosci. 2018 Nov 6;10:353

2 Shen H, Liang P, Qiu S, Zhang B, Wang Y, Lv P. The role of Na+, K+-ATPase in the hypoxic vasoconstriction in isolated rat basilar artery. Vascul Pharmacol. 2016,Jun 81:53-60.

3 Lv P, Kim HJ, Lee HJ, Sihn CR, Fathabad SG, Mousavi-Nik A Wang W,   Doyle JK,  Wang G,  Gratton MA, Yamoah EN. Genetic, Cellular and Functional Evidence for Ca2+ Inflow through Cav1.2 and Cav1.3 Channels in Murine Spiral Ganglion Neurons. 2014, J Neurosci May 21, 2014,34(21):7383?C7393

4 Lv P, Sihn CR, Wang W, Shen H, Kim HJ, Rocha-Sanchez SM, Yamoah EN. Posthearing Ca2+ currents and their roles in shaping the different modes of firing of spiral ganglion neurons. 2012, J Neurosci. 14;32(46):16314-30

5 Lv P, Wei D, Yamoah EN. KCNQ-type currents in spiral ganglia neurons involvement in progressive sensorineural hearing loss. 2010 J. Biol Chem 285 34699-707

6 Lv P, Rodriguez-Contreras A, Kim HJ, Zhu J, Wei D, Sihn CR, Eastwood E, Mu K, Levic S, Song H, Petrov Y, Smith PJS,  and Yamoah EN. Release and elementary mechanisms of nitric oxide in hair cells. 2010. J Neurophysiol. 103(5) 2494-505

7 Zhang XD, Lee JH, Lv P, Chen WC, Kim HJ, Wei D, Wang W, Sihn CR, Doyle KJ, Rock JR, Chiamvimonvat N, Yamoah EN.  Etiology of distinct membrane excitability in pre- and posthearing auditory neurons relies on activity of Cl- channel TMEM16A. Proc Natl Acad Sci U S A. 2015 Feb 24;112(8):2575-80

8 Wang W, Kim HJ, Lv P, Tempel B, Yamoah EN. Association of Kv1 family of K+ channels and their functional blueprint in the properties of auditory neurons as revealed by genetic and functional analyses. J Neurophysiol. 2013 110(8):1751-64

9 Yang J, Bouvron S, Lv P, Chi F, Yamoah EN. Functional features of trans-differentiated hair cells mediated by atoh1 reveals a primordial mechanism. J Neurosci. 2012 Mar 14;32(11):3712-25

10 Shen H, Lv P, Xing X, Xing L, Yan X, Wang J, Zhang X . Impairment of alveolar type-II cells involved in the toxicity of Aflatoxin G(1) in rat lung. Food Chem Toxicol. 2012 Sep;50(9):3222-8

11 Kim HJ, Lv P, Sihn CR, and Yamoah EN. Cellular and molecular mechanisms of autosomal dominant form of progressive hearing loss, DFNA2. 2011. J. Biol Chem. 286(2): 1517-27

12 Levic S, Lv P, Yamoah EN. The activity of spontaneous action potentials in developing hair cells is regulated by ca-dependence of a transient k current. PLoS One. 2011 ;6(12):e29005.

13 Wu T, Lv P, Kim HJ, Yamoah EN, Nuttall AL. Effect of Salicylate on KCNQ4 of the guinea pig outer hair cell. J Neurophysiol ,2010. 103(4):1969-77.

14 Rodriguez-Contreras, A., Lv, P., Zhu J, & Yamoah, E.N. Effects of strontium on the permeation and gating phenotype of calcium channels in hair cells. 2008. J. Neurophysiol. 100:2115-2124

15 Shao P, Guo N, Wang C, Zhao M, Yi L, Liu C, Kang L, Cao L, Lv P, Xing L, Zhang X, Shen H. Aflatoxin G1 induced TNF-α-dependent lung inflammation to enhance DNA damage in alveolar epithelial cells. J Cell Physiol. 2019 Jun;234(6):9194-9206.


科研项目:

1. “螺旋神经元KCNQ4钾通道在老年性耳聋中作用及其机制研究” 国家自然科学基金(面上项目) (81670939) 58万 (2017-2020)

2. “Cav3钙通道介导年龄相关性听力损失的机制研究”河北省自然科学基金(面上项目)(H2018206265)6万(2018-2020)

3. “螺旋神经元电压依赖性钙离子通道功能改变与老年性耳聋关系的研究” 国家自然科学基金青年基金(81200746)23万 (2013-2015)

4. “螺旋神经元HCN通道的功能改变与年龄相关性听力损失关系的研究” 教育部博士点基金(新教师类)(20121323120005)  4万(2013-2015)

5. “耳蜗螺旋神经元HCN通道功能改变与老年性耳聋关系的研究”  河北省自然科学基金(青年基金)(C2013206251) 3万(2013-2015)

6. 耳蜗螺旋神经元HCN通道参与老年性耳聋机制的研究” 教育部留学回国人员科研启动基金 3万 (2013-2015)

7. “T型钙通道在老年性耳聋中的作用及机制研究”河北省教育厅重点项目 (ZD 2015010) 5万 (2015-2017)

8. “螺旋神经元HCN通道的功能以及在老年性耳聋中的作用”河北省高层次人才资助项目 (D2012003051)3万 (2013-2015)