王磊，教授，博士研究生导师。本科及硕士毕业于中国药科大学药物化学专业，博士毕业于美国Duquesne University药物化学专业。现任太阳成集团tyc33455cc副院长，兼任河北省药学会药物化学专业委员会主任委员、河北省毒理学会理事。主要从事药物分子设计与合成、药物作用的分子机制和新药研究。主持国家自然科学基金、教育部科学技术研究重点项目，中国博士后基金、河北省科技厅重点研发计划项目、河北省自然科学基金项目。河北省“三三三人才工程”第三层次人选。

主持科研项目：

1.国家自然科学基金面上项目，82073681，设计合成FR-β/PI3Kγ靶向嵌合分子调控TAM极化作用及抗肿瘤免疫机制研究，2021-2024。

2.国家自然科学基金青年基金，81202401，PCFT 为转运靶的新型选择性GARFTase 抑制剂的研究，2013-2015。

3.教育部科学技术研究重点项目，212014，特异性被PCFT转运的新型GARFTase抑制剂的研究，2012-2014。

4.中国博士后基金特别资助项目，2014T70228，GARFTase抑制剂偶联抗肿瘤药物小分子的合成及活性研究，2014-2015。

5.中国博士后基金一等资助项目，2013M540214，新型高选择性甘氨酰核苷酸甲基转移酶抑制剂的研究，2013-2013。

6.河北省自然科学基金面上项目，H2020206548，基于FR-β/PI3Kγ的嵌合分子设计、合成及靶向调控肿瘤相关巨噬细胞极化作用，2020-2022。

7.河北省自然科学基金面上项目，H2017206291，多靶点叶酸类似物小分子作为高选择性靶向抗肿瘤药物的探索，2017-2019。

8.河北省自然科学基金青年基金，H2013206211，PCFT为转运靶的新型选择性GARFTase抑制剂的研究，2013-2015。

代表论文：

1.Gao, T.; Zhang, C.; Shi, X.; Guo, R.; Zhang, K.; Gu, J.; Li, L.; Li, S.; Zheng, Q.; Cui, M.; Cui, M.; Gao, X.; Liu, Y.*; Wang, L.* Targeting dihydrofolate reductase: Design, synthesis and biological evaluation of novel 6-substituted pyrrolo[2,3-d]pyrimidines as nonclassical antifolates and as potential antitumor agents. European Journal of Medicinal Chemistry, 2019, 178, 329-340.

2.Xing, R.; Zhang, H.; Yuan, J.; Zhang, K.; Li, L.; Guo, H.; Zhao, L.; Zhang, C.; Li, S.; Gao, T.; Liu, Y.*; Wang, L.* Novel 6-substituted benzoyl and non-benzoyl straight chain pyrrolo[2,3-d]pyrimidines as potential antitumor agents with multitargeted inhibition of TS, GARFTase and AICARFTase. European Journal of Medicinal Chemistry, 2017, 139, 531-541.

3.Liu, Y.; Li, M.; Zhang, H.; Yuan, J.; Zhang, C.; Zhang, K.; Guo, H.; Zhao, L.; Du, Y.; Wang, L.*; Ren, L.* Design, synthesis and biological evaluation of 6-substituted pyrrolo[2,3-d]pyrimidines as dual inhibitors of TS and AICARFTase and as potential antitumor agents. European Journal of Medicinal Chemistry, 2016, 115, 245-256.

4.Wang, L.; Wallace, A.; Raghavan, S.; Deis, S.M.; Wilson, M.R.; Yang, S.; Polin, L.; White, K.; Kushner, J.; Orr, S.; George, C.; O'Connor, C.; Hou, Z.; Mitchell-Ryan, S.; Dann, C.E. 3rd; Matherly, L.H.; Gangjee, A. 6-Substituted Pyrrolo[2,3-d]pyrimidine Thienoyl Regioisomers as Targeted Antifolates for Folate Receptor α and the Proton-Coupled Folate Transporter in Human Tumors. Journal of Medicinal Chemistry, 2015, 58, 6938-6959.

5.Liu, Y.; Zhang, C.; Zhang, H.; Li, M.; Yuan, J.; Zhang, Y.; Zhou, J.; Guo, H.; Zhao, L.; Du, Y.; Wang, L.*; Ren, L.* Synthesis and antitumor activity of a novel series of 6-substituted pyrrolo[2,3-d]pyrimidines as potential nonclassical antifolates targeting both thymidylate and purine nucleotide biosynthesis. European Journal of Medicinal Chemistry, 2015, 93, 142-155.

6.Wang, L.; Cherian, C; Kugel-Desmoulin, S.; Mitchell-Ryan, S; Hou, Z.; Matherly, L. H. and Gangjee, A. Synthesis and Biological Activity of 6-Substituted Pyrrolo[2,3-d]pyrimidine Thienoyl Regioisomers as Inhibitors of de Novo Purine Biosynthesis with Selectivity for Cellular Uptake by High Affinity Folate Receptors and the Proton-Coupled Folate Transporter over the Reduced Folate Carrier. Journal of Medicinal Chemistry, 2012, 55, 1758-1770.

7.Wang, L.; Kugel-Desmoulin, S.; Cherian, C; Polin, L.; White, K.; Kushner, J.; Fulterer, A.; Chang, M.; Mitchell-Ryan, S.; Stout, M.; Romero, M. F.; Hou, Z.; Matherly, L. H. and Gangjee, A. Synthesis, Biological and Antitumor Activity of a Highly Potent 6-Substituted Pyrrolo[2,3-d]pyrimidine Thienoyl Antifolate Inhibitor with Proton-Coupled Folate Transporter and Folate Receptor Selectivity over the Reduced Folate Carrier That Inhibits β-Glycinamide Ribonucleotide Formyltransferase. Journal of Medicinal Chemistry, 2011, 54, 7150–7164. 

8.Wang, L.; Cherian, C; Kugel-Desmoulin, S.; Polin, L.; Deng, Y.; Wu, J.; Hou, Z.; White, K.; Kushner, J.; Matherly, L. H. and Gangjee, A. Synthesis and Antitumor Activity of a Novel Series of 6-Substituted Pyrrolo[2,3-d]pyrimidine Thienoyl Antifolate Inhibitors of Purine Biosynthesis with Selectivity for High Affinity Folate Receptors and the Proton-Coupled Folate Transporter over the Reduced Folate Carrier for Cellular Entry. Journal of Medicinal Chemistry, 2010, 53, 1306–1318.