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孔德志博士-副教授

发布时间:2016-10-12   浏览次数:0

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孔德志,男,博士,副教授,中药与中药药理教研室主任。主要从事基于质谱技术的多组学研究,擅长应用蛋白质组学研究中药及其有效成分的作用机制、作用靶点。主持及参与国家自然科学基金、国家重大新药创制专项、河北省自然科学基金、河北省教育厅基金等项目10余项;发表SCI及CSCD论文30余篇。目前是《中国药理学会补益药药理专业委员会》学术委员、《中国药理学会麻醉药理专业委员会》学术青年委员、《中国药理学会神经药理专业委员会》学术青年委员、《世界科学技术-中医药现代化》杂志的中青年编委、河北省及石家庄市科技专家库成员。近三年发表论文如下:

1.TXNIP, a novel key factor to cause Schwann cell dysfunction in diabetic peripheral neuropathy, under the regulation of PI3K/Akt pathway inhibition-induced DNMT1 and DNMT3a overexpression. Cell death & disease, 2021,12: 642-642

2.Differential modulation of SK channel subtypes by phosphorylation. Cell Calcium. 2021, 94:102346.4:102346.

3.β-Glucan ameliorates nonalcoholic steatohepatitis induced by methionine and choline-deficient diet in mice. J FOOD BIOCHEM 2020. 44: e13408

4.Cannabidiol inhibits febrile seizure by modulating AMPA receptor kinetics through its interaction with the N-terminal domain of GluA1/GluA2. PHARMACOL RES 2020;161:105128.

5.Metformin Enhances Antidepressant/Antipsychotic Combination Therapy of Schizophrenia With Comorbid Depression in a Murine Model. FRONT NEUROSCI-SWITZ 2020;14.

6.Rethinking Schizophrenia and Depression Comorbidity as One Psychiatric Disorder Entity: Evidence From Mouse Model. FRONT NEUROSCI-SWITZ 2020;14.

7.利用电子顺磁波谱技术研究红参对羟自由基的清除作用. 世界科学技术-中医药现代化 2020;22(04):1255-1261

8.Mitochondrial metabolic study guided by proteomics analysis in hepatocellular carcinoma cells surviving long-term incubation with the highest dose of sorafenib, Aging (Albany NY). 2019, 11(24):12452-12475. 

9.Screening and identification of potential tyrosinase inhibitors from Semen Oroxyli extract by ultrafiltration LC-MS and in silico molecular docking. J CHROMATOGR SCI 2019;57(9):838-846

10.Revealing the Inhibitory Effect of Ginseng on Mitochondrial Respiration through Synaptosomal Proteomics: PROTEOMICS, 2018, 18(11):e1700354

11.乳鼠及成年大鼠脑皮质膜蛋白差异的分析[J].中国药理学通, 2018, 34(08): 1179-1184.

12.基于Shotgun液相质谱联用技术研究膜蛋白组学的进展,世界科学技术-中医药现代化, 2018, 20(08):1329-1336